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2008 1
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33 results

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Page 1
Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.
Cotte AK, Aires V, Fredon M, Limagne E, Derangère V, Thibaudin M, Humblin E, Scagliarini A, de Barros JP, Hillon P, Ghiringhelli F, Delmas D. Cotte AK, et al. Nat Commun. 2018 Jan 22;9(1):322. doi: 10.1038/s41467-017-02732-5. Nat Commun. 2018. PMID: 29358673 Free PMC article.
Here we show that LD content of CRC cells positively correlates with the expression of lysophosphatidylcholine acyltransferase 2 (LPCAT2), an LD-localised enzyme supporting phosphatidylcholine synthesis. ...Notably, droplet accumulation is associated w …
Here we show that LD content of CRC cells positively correlates with the expression of lysophosphatidylcholine acyltransferase …
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS.
Abate W, Alrammah H, Kiernan M, Tonks AJ, Jackson SK. Abate W, et al. Sci Rep. 2020 Jun 25;10(1):10355. doi: 10.1038/s41598-020-67000-x. Sci Rep. 2020. PMID: 32587324 Free PMC article.
In this study we have used RNAi technology to show, for the first time, that the inducible lysophosphatidylcholine acyltransferase 2 (LPCAT2) plays a key role in macrophage inflammatory gene expression in response to stimulation with bacterial ligands. …
In this study we have used RNAi technology to show, for the first time, that the inducible lysophosphatidylcholine acyltransferase …
Mitochondrial Reactive Oxygen Species Formation Determines ACSL4/LPCAT2-Mediated Ferroptosis.
Merkel M, Goebel B, Boll M, Adhikari A, Maurer V, Steinhilber D, Culmsee C. Merkel M, et al. Antioxidants (Basel). 2023 Aug 9;12(8):1590. doi: 10.3390/antiox12081590. Antioxidants (Basel). 2023. PMID: 37627584 Free PMC article.
The enzymes acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase (LPCAT) play an essential role in the biosynthesis of polyunsaturated fatty acid (PUFA)-containing phospholipids, thereby providing the substrates for lipi …
The enzymes acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase (LPCAT) play an …
Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.
Hamano F, Matoba K, Hashidate-Yoshida T, Suzuki T, Miura K, Hishikawa D, Harayama T, Yuki K, Kita Y, Noda NN, Shimizu T, Shindou H. Hamano F, et al. FASEB J. 2021 Jun;35(6):e21501. doi: 10.1096/fj.202002591R. FASEB J. 2021. PMID: 33956375
PAF is biosynthesized by two types of lyso-PAF acetyltransferases: lysophosphatidylcholine acyltransferase 1 (LPCAT1) and LPCAT2, which are constitutive and inducible forms of lyso-PAF acetyltransferase, respectively. ...Although the structure of LPCAT2 …
PAF is biosynthesized by two types of lyso-PAF acetyltransferases: lysophosphatidylcholine acyltransferase 1 (LPCAT1) and L …
Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages.
Morimoto R, Shindou H, Oda Y, Shimizu T. Morimoto R, et al. J Biol Chem. 2010 Sep 24;285(39):29857-62. doi: 10.1074/jbc.M110.147025. Epub 2010 Jul 27. J Biol Chem. 2010. PMID: 20663880 Free PMC article.
We have recently identified two enzymes involved in PAF production: lysophosphatidylcholine acyltransferase-1 (LPCAT1) and LPCAT2. We found that LPCAT2 is highly expressed in inflammatory cells and is activated by lipopolysaccharide (LPS) treatment thr …
We have recently identified two enzymes involved in PAF production: lysophosphatidylcholine acyltransferase-1 (LPCAT1) and …
Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2.
Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T. Tarui M, et al. J Lipid Res. 2014 Jul;55(7):1386-96. doi: 10.1194/jlr.M049205. Epub 2014 May 21. J Lipid Res. 2014. PMID: 24850807 Free PMC article.
Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the lungs where it produces PAF and dipalmitoyl-phosphatidylcholine essential for respiration, and LPCAT2, which biosynthesizes PAF and p …
Previously, we identified two types of lyso-PAFATs: lysophosphatidylcholine acyltransferase (LPCAT)1, mostly expressed in the …
LPCAT2 controls chemoresistance in colorectal cancer.
Cotte AK, Aires V, Ghiringhelli F, Delmas D. Cotte AK, et al. Mol Cell Oncol. 2018 Apr 11;5(3):e1448245. doi: 10.1080/23723556.2018.1448245. eCollection 2018. Mol Cell Oncol. 2018. PMID: 30250902 Free PMC article.
We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell …
We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 …
Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop.
Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T. Shindou H, et al. FASEB J. 2017 Jul;31(7):2973-2980. doi: 10.1096/fj.201601183R. Epub 2017 Mar 24. FASEB J. 2017. PMID: 28341636 Free PMC article.
In the present study, we found that pain-like behaviors resulting from partial sciatic nerve ligation (PSL) were largely attenuated by deficiency of lysophosphatidylcholine acyltransferase (LPCAT)2, which is one of the PAF biosynthetic enzymes. By contrast, d …
In the present study, we found that pain-like behaviors resulting from partial sciatic nerve ligation (PSL) were largely attenuated by defic …
Rapid production of platelet-activating factor is induced by protein kinase Calpha-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein.
Morimoto R, Shindou H, Tarui M, Shimizu T. Morimoto R, et al. J Biol Chem. 2014 May 30;289(22):15566-76. doi: 10.1074/jbc.M114.558874. Epub 2014 Apr 17. J Biol Chem. 2014. PMID: 24742674 Free PMC article.
We have reported previously that lyso-PAFAT activity is enhanced in three distinct ways in mouse macrophages: rapid activation (30 s) after PAF stimulation and minutes to hours after LPS stimulation. Lysophosphatidylcholine acyltransferase 2 (LPCAT2) w …
We have reported previously that lyso-PAFAT activity is enhanced in three distinct ways in mouse macrophages: rapid activation (30 s) after …
LPCAT2 Methylation, a Novel Biomarker for the Severity of Cedar Pollen Allergic Rhinitis in Japan.
Watanabe H, Miyake K, Matsuoka T, Kojima R, Sakurai D, Masuyama K, Yamagata Z. Watanabe H, et al. Am J Rhinol Allergy. 2021 Sep;35(5):631-639. doi: 10.1177/1945892420983646. Epub 2020 Dec 23. Am J Rhinol Allergy. 2021. PMID: 33356413
We analyzed DNA methylation of acyl-CoA thioesterase 7 (ACOT7), mucin 4 (MUC4), schlafen 12 (SLFN12), lysophosphatidylcholine acyltransferase 2 (LPCAT2), and interleukin-4 (IL4) in PBMCs and NMSCs using bisulfite next-generation sequencing; the correla …
We analyzed DNA methylation of acyl-CoA thioesterase 7 (ACOT7), mucin 4 (MUC4), schlafen 12 (SLFN12), lysophosphatidylcholine acyl …
33 results